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Optimal Stabilization of Boolean Networks through Collective Influence

机译:集体影响下布尔网络的最优镇定

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摘要

The stability of Boolean networks has attracted much attention due to itswide applications in describing the dynamics of biological systems. During thepast decades, much effort has been invested in unveiling how network structureand update rules will affect the stability of Boolean networks. In this paper,we aim to identify and control a minimal set of influential nodes that iscapable of stabilizing an unstable Boolean network. By minimizing the largesteigenvalue of a modified non-backtracking matrix, we propose a method using thecollective influence theory to identify the influential nodes in Booleannetworks with high computational efficiency. We test the performance ofcollective influence on four different networks. Results show that thecollective influence algorithm can stabilize each network with a smaller set ofnodes than other heuristic algorithms. Our work provides a new insight into themechanism that determines the stability of Boolean networks, which may findapplications in identifying the virulence genes that lead to serious disease.
机译:布尔网络的稳定性由于其在描述生物系统动力学方面的广泛应用而备受关注。在过去的几十年中,已投入大量精力来揭示网络结构和更新规则将如何影响布尔网络的稳定性。在本文中,我们旨在识别和控制能够稳定不稳定布尔网络的最小影响节点集。通过最小化修改后的非回溯矩阵的最大特征值,我们提出了一种使用集体影响理论来识别布尔网络中影响节点的方法,具有很高的计算效率。我们测试了在四个不同网络上集体影响的表现。结果表明,与其他启发式算法相比,集体影响算法可以用较小的节点集来稳定每个网络。我们的工作为确定布尔网络稳定性的主题机制提供了新的见解,这可能会在识别导致严重疾病的致病基因中找到应用。

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